Description

(2S,4R)-(9H-Fluoren-9-Yl)Methyl 4-Hydroxy-2-(Hydroxymethyl)Pyrrolidine-1-Carboxylate is a high-purity, chiral pyrrolidine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its role as a protected amino acid or amino alcohol synthon, enabling the stereoselective construction of complex pharmaceutical intermediates. This compound is essential for research and development chemists in the pharmaceutical and biotechnology sectors, particularly those focused on peptide mimetics, protease inhibitors, and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for antiviral and anticancer drug candidates.
• Peptidomimetic Research: Used to construct non-natural amino acid scaffolds that mimic peptide structures for drug discovery.
• Protease Inhibitor Development: Serves as a core structural element in the design of inhibitors targeting specific enzymatic pathways.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block to induce stereoselectivity in complex organic reactions.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high stereochemical purity.

Basic Information

Item	Detail
Product Name	(2S,4R)-(9H-Fluoren-9-Yl)Methyl 4-Hydroxy-2-(Hydroxymethyl)Pyrrolidine-1-Carboxylate
CAS No.	163671-09-8
Molecular Formula	C21H21NO4
Molecular Weight	351.40 g/mol
Synonyms	Fmoc-4-hydroxy-2-(hydroxymethyl)pyrrolidine; (2S,4R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-hydroxy-2-(hydroxymethyl)pyrrolidine; Fmoc-Thp-OH; 1-Fmoc-4-hydroxy-2-(hydroxymethyl)pyrrolidine; (2S,4R)-N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-hydroxy-2-(hydroxymethyl)pyrrolidine; 4-Hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester; (2S,4R)-Fmoc-4-Hyp(2-CH2OH)
EINECS	Contact for details

Quality Control

Our (2S,4R)-(9H-Fluoren-9-Yl)Methyl 4-Hydroxy-2-(Hydroxymethyl)Pyrrolidine-1-Carboxylate is manufactured under strict quality systems to ensure batch-to-batch consistency and high stereochemical purity, suitable for demanding research and cGMP starting material applications. All products undergo rigorous analytical testing, including HPLC, chiral HPLC, 1H/13C NMR, and mass spectrometry, to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) with full analytical data are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.