Description

Fmoc-D-Trp(Boc)-Oh is a high-purity, orthogonally protected amino acid derivative essential for modern solid-phase peptide synthesis (SPPS). This compound is specifically engineered to facilitate the controlled and efficient construction of complex peptides, ensuring high coupling yields and minimizing side reactions. It is a critical building block for pharmaceutical R&D, biotechnology, and academic research focused on developing novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected building block for the automated or manual synthesis of custom peptides.
• Pharmaceutical Research: Used in the discovery and development of peptide drugs, including hormone analogs, antimicrobial peptides, and targeted therapeutics.
• Peptide Library Production: Essential for creating combinatorial peptide libraries for high-throughput screening in drug discovery and epitope mapping.
• Bioconjugation: Serves as a precursor for introducing the tryptophan moiety into larger biomolecules or synthetic constructs.
• Academic & Biochemical Research: Employed in studying protein-protein interactions, enzyme substrates, and structure-activity relationships (SAR).
• Production of Protected Peptide Fragments: Used in fragment condensation strategies for synthesizing long or difficult peptide sequences.

Basic Information

Product Name	Fmoc-D-Trp(Boc)-Oh
CAS No.	163619-04-3
Molecular Formula	C31H30N2O6
Molecular Weight	526.58 g/mol
Synonyms	Fmoc-D-tryptophan(Boc)-OH; N-α-Fmoc-N-ω-Boc-D-tryptophan; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-((tert-butoxycarbonyl)indol-3-yl)propanoic acid; Fmoc-D-Trp(Boc)-OH; N-Fmoc-N'-Boc-D-tryptophan; Boc-D-Trp(Fmoc)-OH; D-Tryptophan, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-[1,1-dimethylethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Fmoc-D-Trp(Boc)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity	≥99.0% D-isomer
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.