Description

5-Fluoro-2-Methylphenylboronic Acid is a versatile organoboron compound that serves as a critical building block in modern synthetic chemistry. Its primary value lies in its role as a key reagent in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to develop novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing fluorinated biphenyl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the stability imparted by the fluorine and methyl substituents.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where precise molecular architecture is required.
• Ligand and Catalyst Development: Serves as a starting material for creating novel boron-containing ligands and catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes.
• Custom Synthesis & Contract Manufacturing: A fundamental reagent for custom synthesis houses and CROs/CMOs serving the life sciences industry.

Basic Information

Product Name	5-Fluoro-2-Methylphenylboronic Acid
CAS No.	163517-62-2
Molecular Formula	C7H8BFO2
Molecular Weight	153.95 g/mol
Synonyms	(5-Fluoro-2-methylphenyl)boronic acid; 2-Methyl-5-fluorophenylboronic acid; 5-Fluoro-o-tolylboronic acid; Boronic acid, B-(5-fluoro-2-methylphenyl)-; 5-Fluoro-2-methylbenzeneboronic acid; 163517-62-2; 5-Fluoro-2-methylphenyl-B(OH)2
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Methylphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive cross-coupling reactions. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Assay (NMR)	≥95.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.