Description

Boc-D-Orn(Fmoc)-OH is a protected, non-proteinogenic amino acid derivative essential for advanced peptide synthesis. This compound is specifically engineered to provide orthogonal protection for the side chain and α-amino group, enabling precise, sequential deprotection strategies in complex peptide assembly. It is a critical building block for researchers and manufacturers in pharmaceutical development, particularly for creating peptide-based therapeutics, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of D-ornithine residues using Fmoc/t-Bu chemistry.
• Pharmaceutical Research: Synthesis of novel peptide drug candidates, including antimicrobial peptides (AMPs) and hormone analogs.
• Bioconjugation: Used to introduce functional handles or fluorescent labels into peptides and proteins via the orthogonal protecting groups.
• Combinatorial Chemistry: Serves as a valuable building block in libraries for high-throughput screening of bioactive peptides.
• Academic & Industrial R&D: Fundamental research in peptide structure-activity relationships (SAR) and chemical biology.

Basic Information

Product Name	Boc-D-Orn(Fmoc)-OH
CAS No.	163336-15-0
Molecular Formula	C₂₅H₃₀N₂O₆
Molecular Weight	454.52 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-N-δ-(9-fluorenylmethoxycarbonyl)-D-ornithine; Boc-D-Orn(Fmoc); (2R)-5-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid; tert-Butyl N-[(1R)-5-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-carboxypentyl]carbamate; D-Orn(Boc,Fmoc)-OH; Boc-D-Ornithine(Fmoc)-OH
EINECS	Contact for details

Quality Control

Our Boc-D-Orn(Fmoc)-OH is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity, ensuring compliance with research and development standards. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.