Description

Ac-Gln(Trt)-Oh CAS NO 163277-79-0 is a protected glutamine derivative, specifically N-acetyl-N-trityl-L-glutamine, widely used as a key building block in peptide synthesis. This compound is essential for researchers and manufacturers requiring precise control over glutamine incorporation while preventing unwanted side reactions during complex peptide assembly. It is a critical intermediate for pharmaceutical R&D, particularly in the development of therapeutic peptides and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected glutamine residue to prevent side-chain cyclization and racemization during coupling steps.
• Solution-Phase Peptide Synthesis: Used in the synthesis of complex peptides and small proteins where selective deprotection is required.
• Pharmaceutical Intermediate: A crucial building block in the research and production of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation & Labeling: Provides a handle for site-specific modification of peptides due to its protected side chain.
• Chemical Biology Research: Employed in the study of protein-protein interactions and the development of peptide probes.
• Custom Peptide Service: A standard reagent used by CROs and CDMOs for manufacturing client-specific peptide sequences.

Basic Information

Product Name	Ac-Gln(Trt)-Oh
CAS No.	163277-79-0
Molecular Formula	C28H29NO4
Molecular Weight	443.54 g/mol
Synonyms	N-Acetyl-N-trityl-L-glutamine; Nα-Acetyl-Nω-trityl-L-glutamine; Ac-Gln(Trt)-OH; L-Glutamine, N-acetyl-N-(triphenylmethyl)-; N-Acetyl-N-tritylglutamine; Ac-Gln(Trt)-OH (peptide synthesis grade); Nα-Acetyl-Nω-tritylglutamic acid 5-amide
EINECS	Contact for details

Quality Control

Every batch of Ac-Gln(Trt)-Oh is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments. Our quality standards are designed to meet the rigorous demands of pharmaceutical R&D and GMP-grade peptide synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	-15.0° to -19.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.