Description

Ac-Arg(Pmc)-Oh is a protected arginine derivative, a critical building block in solid-phase peptide synthesis (SPPS). Its value lies in providing precise control over peptide chain assembly by safeguarding the reactive guanidino group of arginine, thereby preventing side reactions and improving yield and purity. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research requiring the synthesis of complex peptides and proteins.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the sequential construction of peptide chains on resin.
• Pharmaceutical Intermediate: Used in the research and production of therapeutic peptides targeting various diseases.
• Bioconjugation and Protein Engineering: Serves as a modified amino acid precursor for creating site-specifically labeled proteins or functionalized biomolecules.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for drug discovery and screening.
• Academic and R&D Laboratories: Fundamental reagent for studying peptide structure, function, and synthesis methodologies.
• GMP Manufacturing: Suitable for use in the synthesis of peptide active pharmaceutical ingredients (APIs) under controlled conditions.

Basic Information

Product Name	Ac-Arg(Pmc)-Oh
CAS No.	163277-77-8
Molecular Formula	C24H39N5O6S
Molecular Weight	525.66 g/mol
Synonyms	Nα-Acetyl-Nω-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-arginine; Acetyl-L-arginine(Pmc)-OH; Ac-Arg(Pmc)-OH; N-Acetyl-N'-Pmc-L-arginine; Fmoc-Arg(Pmc)-OH precursor; Protected Arginine derivative; Peptide synthesis building block; SPPS reagent
EINECS	Contact for details

Quality Control

Our Ac-Arg(Pmc)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemical and pharmaceutical intermediates, ensuring material suitability for advanced research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.