Description

(S)-4-tert-Butyl-2-[(Sp)-2-(Diphenylphosphino)Ferrocenyl]-2-Oxazoline is a highly specialized chiral ferrocenyl phosphine-oxazoline ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity in a wide range of transition-metal-catalyzed reactions, enabling the efficient synthesis of single-enantiomer compounds. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control.

Application

• Asymmetric hydrogenation of olefins, ketones, and imines for pharmaceutical intermediate synthesis.
• Enantioselective C–C bond-forming reactions, including allylic alkylation and Heck reactions.
• Catalyst ligand for rhodium, iridium, and palladium complexes in academic and industrial research.
• Development of novel catalytic processes for the production of chiral active pharmaceutical ingredients (APIs).
• Key component in catalyst screening kits for high-throughput experimentation (HTE) in drug discovery.
• Precursor for the synthesis of more complex, tailored bidentate and tridentate ligand systems.

Basic Information

Product Name	(S)-4-tert-Butyl-2-[(Sp)-2-(Diphenylphosphino)Ferrocenyl]-2-Oxazoline
CAS No.	163169-15-1
Molecular Formula	C31H32FeNOP
Molecular Weight	521.41 g/mol
Synonyms	(S)-t-Bu-PHOX; (S)-4-tert-Butyl-2-[(S)-2-(Diphenylphosphino)ferrocen-1-yl]-4,5-dihydrooxazole; (S)-4-(tert-Butyl)-2-[(Sp)-2-(diphenylphosphanyl)ferrocen-1-yl]-4,5-dihydrooxazole; (S,Sp)-FerrocenylPHOX; (S)-4-tert-Butyl-2-[(Sp)-2-(diphenylphosphanyl)ferrocenyl]-2-oxazoline; tBuPHOX Ferrocenyl Ligand; Josiphos-type oxazoline ligand; Chiral ferrocenyl P,N-ligand
EINECS	Contact for details

Quality Control

Our (S)-4-tert-Butyl-2-[(Sp)-2-(Diphenylphosphino)Ferrocenyl]-2-Oxazoline is manufactured under strict quality protocols to ensure batch-to-batch consistency and high ligand purity, which is critical for catalytic performance. Each lot is characterized by NMR (1H, 31P, 13C), HPLC, and optical rotation analysis to confirm identity, purity, and enantiomeric integrity. Certificates of Analysis (COA) with full analytical data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry place at 2-8°C for long-term stability. This compound is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.