Description

(2R)-1-[(4S)-4,5-Dihydro-4-Phenyl-2-Oxazolyl]-2-(Diphenylphosphino)-Ferrocene is a highly specialized chiral ferrocenyl phosphine-oxazoline ligand, representing a cornerstone of modern asymmetric catalysis. Its core value lies in enabling precise stereochemical control in critical carbon-carbon and carbon-heteroatom bond-forming reactions, which is essential for producing enantiomerically pure intermediates. This compound is indispensable for R&D and production chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high-performance, reliable catalysts for complex synthetic routes.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, crucial for synthesizing chiral pharmaceutical building blocks.
• Asymmetric C-C Bond Formation: Catalyzes key reactions such as allylic alkylation, Heck reactions, and conjugate additions with high enantiomeric excess (ee).
• Pharmaceutical Intermediate Synthesis: Used in the production of active pharmaceutical ingredients (APIs) where specific chirality is required for biological activity.
• Agrochemical Manufacturing: Enables the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical and Fragrance Production: Applied in the creation of complex, high-value chiral molecules for flavors, fragrances, and advanced materials.
• Academic and Industrial R&D: A vital tool for methodology development and exploring new catalytic transformations in both academic and corporate research laboratories.

Basic Information

Product Name	(2R)-1-[(4S)-4,5-Dihydro-4-Phenyl-2-Oxazolyl]-2-(Diphenylphosphino)-Ferrocene
CAS No.	163169-12-8
Molecular Formula	C31H26FeNOP
Molecular Weight	515.37 g/mol
Synonyms	(R,S)-PF-Phox; (R)-(S)-PF-Phox; Ferrocenylphosphino-oxazoline ligand; Josiphos-type ligand; (R)-1-[(S)-4,5-Dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene; (2R)-1-[(4S)-4,5-Dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene; Chiral Ferrocenyl Phosphine-Oxazoline Ligand; 163169-12-8
EINECS	Contact for details

Quality Control

Our (2R)-1-[(4S)-4,5-Dihydro-4-Phenyl-2-Oxazolyl]-2-(Diphenylphosphino)-Ferrocene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for catalytic performance. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity, chemical purity, and metal content. We support compliance with cGMP and ISO standards for advanced chemical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation, the container should only be opened in an inert environment.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.