Description

Human Betacellulin is a potent mitogenic polypeptide belonging to the epidermal growth factor (EGF) family. This protein plays a critical role in stimulating the proliferation and differentiation of pancreatic beta cells and various epithelial tissues. It is an essential research-grade biochemical for advanced life science and pharmaceutical development. Key industrial and research applications include cell culture studies, regenerative medicine research, and the development of therapeutic agents for diabetes and tissue repair.

Application

• Biomedical Research: Used as a key growth factor in cell culture media to study pancreatic beta cell proliferation, differentiation, and function.
• Diabetes Research: Investigated for its potential therapeutic role in stimulating endogenous β-cell regeneration and islet neogenesis.
• Tissue Engineering & Regenerative Medicine: Employed in studies focusing on the repair and regeneration of epithelial tissues, including the skin, lung, and gastrointestinal tract.
• Drug Discovery & Development: Serves as a critical reference standard and active ingredient in screening assays and preclinical studies for metabolic disorders.
• Cell Signaling Studies: Utilized to elucidate the EGF receptor (EGFR/ErbB) signaling pathways and their implications in development and disease.
• Biopharmaceutical Production: Acts as a process ingredient or a target molecule in the development and manufacturing of recombinant protein therapeutics.

Basic Information

Product Name	Human Betacellulin
CAS No.	163150-12-7
Molecular Formula	C684H1074N184O203S18
Molecular Weight	Approx. 15.5 kDa
Synonyms	Betacellulin; BTC; Recombinant Human Betacellulin; BTC, Human; Betacellulin Precursor; Probetacellulin; Glia-activating factor; GAF; Epidermal Growth Factor Family Member
EINECS	Contact for details

Quality Control

Our Human Betacellulin is produced under stringent conditions to ensure the highest standards of purity and biological activity. Each batch undergoes comprehensive analytical testing, including SDS-PAGE, HPLC for purity assessment, and endotoxin level determination. Certificates of Analysis (COA) detailing purity, potency (ED50), and sterility are provided to guarantee consistency and reliability for your critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -20°C to -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the vial is at room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Identification (HPLC/MS)	Conforms to standard
Purity (SDS-PAGE & RP-HPLC)	> 95%
Biological Activity (Cell Proliferation Assay)	ED50 ≤ 5 ng/mL
Endotoxin Level (LAL)	< 1.0 EU/μg
Solubility	Soluble in water or PBS

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.