Description

(Ile76)-Tnf-α (70-80) (Human) is a synthetic peptide fragment derived from the human Tumor Necrosis Factor-Alpha (TNF-α) protein sequence. This high-purity reference standard is critical for advanced biomedical research and assay development, enabling precise study of protein interactions and signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic manufacturers focused on immunology, inflammation, and autoimmune disease research.

Application

• Biomedical Research Standard: Used as a high-purity reference material in quantitative assays for TNF-α and related cytokine studies.
• Immunoassay Development: Serves as a critical antigen for the development and calibration of ELISA, Western Blot, and other immunoassay kits.
• Drug Discovery & Screening: Employed in high-throughput screening (HTS) platforms to identify and validate novel therapeutic compounds targeting TNF-α pathways.
• Antibody Production & Characterization: Acts as an immunogen for generating specific monoclonal or polyclonal antibodies against defined TNF-α epitopes.
• Cell Signaling Studies: Utilized in vitro to investigate the role of specific TNF-α domains in inflammatory response and apoptosis mechanisms.
• Quality Control in Biologics: Functions as a system suitability standard in the QC testing of biopharmaceuticals, including biosimilars targeting TNF-α.

Basic Information

Product Name	(Ile76)-Tnf-α (70-80) (Human)
CAS No.	163045-82-7
Molecular Formula	C66H107N19O19
Molecular Weight	1446.7 g/mol
Synonyms	TNF-α (70-80) (Human); TNF-Alpha Fragment (70-80); Human TNF-α Peptide (70-80); I76-TNF-α (70-80); Tumor Necrosis Factor-Alpha Peptide (residues 70-80); Ile76-TNF-α; H-Tyr-Leu-Ala-Gln-Val-Arg-His-Ser-Ser-Asn-Ile-OH; TLAQV-RHSSNI
EINECS	Contact for details

Quality Control

Every batch of (Ile76)-Tnf-α (70-80) (Human) is manufactured and tested under stringent quality management systems. Our products undergo rigorous analytical testing, including HPLC for purity and MS for identity confirmation, to ensure compliance with research-grade standards. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.