Description

2,2-Difluoroethyl Mesylate is a specialized fluorinated building block and alkylating agent of significant interest in advanced organic synthesis. Its value lies in its ability to introduce the 2,2-difluoroethyl moiety, a key structural feature that can modulate the physicochemical and metabolic properties of target molecules. This compound is primarily needed by research and development teams within the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in medicinal chemistry for creating potential drug candidates.

Application

• Pharmaceutical Intermediate: A critical reagent for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring fluorinated side chains to enhance bioavailability, metabolic stability, or binding affinity.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where fluorine incorporation often leads to improved efficacy and environmental profile.
• Material Science Precursor: Serves as a building block for synthesizing fluorinated polymers, liquid crystals, or specialty materials with unique surface properties.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore the impact of the difluoroethyl group on biological activity.
• Alkylation Agent: Functions as a mesylate ester for efficient O-, N-, or S-alkylation reactions under controlled conditions in complex multi-step syntheses.
• Fluorine Chemistry: A valuable substrate for further functionalization in organofluorine chemistry, enabling the construction of more complex fluorinated architectures.

Basic Information

Product Name	2,2-Difluoroethyl Mesylate
CAS No.	163035-65-2
Molecular Formula	C3H6F2O3S
Molecular Weight	160.14 g/mol
Synonyms	2,2-Difluoroethyl methanesulfonate; Methanesulfonic acid 2,2-difluoroethyl ester; 2,2-Difluoroethanol methanesulfonate; 1,1-Difluoro-2-methanesulfonatoethane; 2,2-Difluoroethyl ester of methanesulfonic acid; DFEM; 163035-65-2 (CAS)
EINECS	Contact for details

Quality Control

Our 2,2-Difluoroethyl Mesylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) and spectroscopic confirmation are provided to guarantee supply reliability and product integrity for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.