Description

(R)-Flurbiprofen-Acyl-β-D-Glucuronide CAS NO 162992-67-8 is a high-purity, chiral metabolite of the non-steroidal anti-inflammatory drug (NSAID) flurbiprofen. This compound is of critical importance for pharmaceutical research and development, serving as a definitive reference standard for analytical and metabolic studies. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug metabolism and pharmacokinetics (DMPK), bioanalytical method development, and impurity profiling.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantification and identification of flurbiprofen metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK): Essential for studying the metabolic pathways, excretion profiles, and pharmacokinetic behavior of (R)-flurbiprofen.
• Bioanalytical Method Development: Used to validate HPLC, LC-MS, and LC-MS/MS methods for accurate metabolite detection and assay in plasma, urine, and other fluids.
• Impurity Profiling: Serves as a known impurity standard to monitor and control the quality of flurbiprofen active pharmaceutical ingredients (APIs) and finished drug products.
• Preclinical & Clinical Research: Supports toxicology studies and clinical trials by enabling precise tracking of the drug's metabolic fate.
• Regulatory Submissions: Provides essential data for regulatory filings (e.g., FDA, EMA) requiring detailed characterization of drug metabolites.

Basic Information

Product Name	(R)-Flurbiprofen-Acyl-β-D-Glucuronide
CAS No.	162992-67-8
Molecular Formula	C25H27FO9
Molecular Weight	490.47 g/mol
Synonyms	(R)-Flurbiprofen Acyl Glucuronide; (R)-Flurbiprofen 1-O-β-Acyl Glucuronide; (2R)-2-(3-Fluoro-4-phenylphenyl)propanoic acid 1-(β-D-glucopyranuronosyl) ester; Flurbiprofen (R-enantiomer) Acyl-β-D-Glucuronide; (R)-Flurbiprofen Glucuronide; FAβG; R-Flurbiprofen AG; Flurbiprofen Acyl Glucuronide (R-Form)
EINECS	Contact for details

Quality Control

Every batch of (R)-Flurbiprofen-Acyl-β-D-Glucuronide is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and strength, meeting the exacting requirements for pharmaceutical reference standards. A detailed Certificate of Analysis (COA) is supplied with each shipment, containing results from orthogonal analytical techniques including HPLC, LC-MS, NMR, and chiral purity analysis.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (R-enantiomer)
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.