Description

(+)-Tetraphos CAS NO 162872-01-7 is a high-purity, enantiomerically pure chiral phosphine ligand, a critical component in asymmetric catalysis. Its value lies in enabling highly selective and efficient chemical transformations, which are essential for producing single-enantiomer intermediates in the pharmaceutical and fine chemical industries. This product is specifically needed by R&D scientists and process chemists working on the synthesis of chiral active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

The primary application of (+)-Tetraphos is as a chiral ligand in transition metal-catalyzed reactions. Its specific uses include:

• Asymmetric Hydrogenation: For the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Asymmetric C-C Bond Formation: Including cross-coupling and allylic substitution reactions to construct complex chiral molecular architectures.
• Pharmaceutical Intermediate Synthesis: Critical for manufacturing chiral building blocks and active pharmaceutical ingredients (APIs) with high enantiomeric excess (ee).
• Agrochemical Production: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical and Fragrance Synthesis: Enabling the production of high-value chiral flavors, fragrances, and specialty chemicals.
• Academic and Industrial R&D: Serving as a key reagent for developing new catalytic methodologies and process optimization.

Basic Information

Product Name	(+)-Tetraphos
CAS No.	162872-01-7
Molecular Formula	C52H44P4
Molecular Weight	804.80 g/mol
Synonyms	(2R,3R)-(-)-2,3-Bis(diphenylphosphino)bicyclo[2.2.1]hept-5-ene; (R,R)-(-)-2,3-Bis(diphenylphosphino)-5-norbornene; (1R,2R)-(-)-1,2-Bis(diphenylphosphino)-5-norbornene; (R,R)-(-)-Norphos; (-)-Norphos; (R,R)-Norphos; Tetraphos ligand; (R,R)-Tetraphos; (1R,2R)-1,2-Bis(diphenylphosphino)-5-norbornene
EINECS	Contact for details

Quality Control

Our (+)-Tetraphos is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized by advanced analytical techniques, including chiral HPLC, 31P NMR, and 1H NMR. We provide comprehensive Certificates of Analysis (COA) detailing purity, enantiomeric excess, and other critical parameters to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (argon or nitrogen) at a controlled room temperature (15-25°C). Keep the container in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
31P NMR	Conforms
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.