Description

4-(Trifluoromethyl)-1,3-Oxazolidin-2-One is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity and physicochemical properties imparted by the trifluoromethyl group and oxazolidinone scaffold, enabling the development of novel compounds with enhanced metabolic stability and bioavailability. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-infectives, and metabolic diseases.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve lipophilicity and biological activity.
• Material Science Research: Serves as a precursor for specialty polymers and advanced materials that require fluorinated components for specific thermal or chemical resistance properties.
• Ligand and Catalyst Development: Employed in the design of novel chiral auxiliaries, ligands for asymmetric catalysis, and organocatalysts due to its rigid, functionalizable structure.
• Fluorine Chemistry Building Block: Essential for medicinal and synthetic chemists exploring structure-activity relationships (SAR) by introducing the CF3 moiety into lead compounds.

Basic Information

Product Name	4-(Trifluoromethyl)-1,3-Oxazolidin-2-One
CAS No.	162684-84-6
Molecular Formula	C4H4F3NO2
Molecular Weight	155.08 g/mol
Synonyms	2-Oxazolidinone, 4-(trifluoromethyl)-; 4-(Trifluoromethyl)-2-oxazolidinone; 4-Trifluoromethyloxazolidin-2-one; 4-Trifluoromethyl-2-oxazolidinone; 4-(Trifluoromethyl)oxazolidin-2-one; 4-(Trifluoromethyl)-1,3-oxazolidin-2-one; 4-(Trifluoromethyl)oxazolidinone
EINECS	Contact for details

Quality Control

We supply 4-(Trifluoromethyl)-1,3-Oxazolidin-2-One in high-purity grades suitable for research and scale-up applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and other analytical methods are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0% (Typical 98-99%)
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.