Description

1-(Fmoc-Amino)Cyclohexanecarboxylic Acid is a key building block in solid-phase peptide synthesis (SPPS), specifically designed for the introduction of a protected amino acid functionality onto a growing peptide chain. Its primary value lies in providing a sterically hindered, cyclohexyl-based backbone that can impart conformational rigidity and influence the pharmacokinetic properties of the final therapeutic peptide. This compound is essential for research institutions and pharmaceutical companies engaged in the development of novel peptide-based drugs, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid derivative for the automated, stepwise construction of complex peptides.
• Peptidomimetic Drug Discovery: Incorporation into peptide analogs to enhance metabolic stability, membrane permeability, and receptor binding affinity.
• Combinatorial Chemistry Libraries: Used as a versatile scaffold for generating diverse compound libraries for high-throughput screening.
• Bioconjugation: Serves as a linker or spacer molecule for coupling peptides to other biomolecules, surfaces, or reporter tags.
• Academic & Industrial Research: Fundamental research tool in medicinal chemistry, biochemistry, and chemical biology for studying protein-protein interactions.

Basic Information

Product Name	1-(Fmoc-Amino)Cyclohexanecarboxylic Acid
CAS No.	162648-54-6
Molecular Formula	C₂₂H₂₃NO₄
Molecular Weight	365.42 g/mol
Synonyms	Fmoc-Ahch-OH; 1-[(9H-Fluoren-9-ylmethoxy)carbonylamino]cyclohexanecarboxylic Acid; N-α-Fmoc-1-amino-1-cyclohexanecarboxylic acid; N-Fmoc-1-amino-cyclohexane-1-carboxylic acid; Fmoc-1-amino-1-cyclohexanecarboxylic acid; Fmoc-Amino-cyclohexyl-carboxylic Acid; (1-(((9H-Fluoren-9-yl)methoxy)carbonylamino)cyclohexane-1-carboxylic acid)
EINECS	Contact for details

Quality Control

Our 1-(Fmoc-Amino)Cyclohexanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.