Description

Methoxycarbonyl-L-tert-Leucine CAS NO 162537-11-3 is a high-purity, non-natural amino acid derivative characterized by its tert-leucine backbone and methoxycarbonyl protecting group. This compound is a critical chiral building block in the synthesis of complex pharmaceutical molecules, offering superior steric hindrance and metabolic stability. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of peptide-based therapeutics, protease inhibitors, and other active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly protease inhibitors and antiviral agents.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the sterically demanding and stable tert-leucine residue.
• API Development: Serves as a crucial building block in the research and commercial production of Active Pharmaceutical Ingredients (APIs).
• Bioconjugation: Employed in the design of peptide-drug conjugates and other bioconjugates due to its reactive carboxylic acid group.
• Chemical Biology Research: Utilized as a tool compound in studying protein-protein interactions and enzyme mechanisms.
• Catalyst Ligand Synthesis: A precursor for synthesizing chiral ligands used in asymmetric catalysis.

Basic Information

Product Name	Methoxycarbonyl-L-tert-Leucine
CAS No.	162537-11-3
Molecular Formula	C9H17NO4
Molecular Weight	203.24 g/mol
Synonyms	(S)-2-[(Methoxycarbonyl)amino]-3,3-dimethylbutanoic acid; L-tert-Leucine, N-methoxycarbonyl-; N-Carbomethoxy-L-tert-leucine; (2S)-2-[(Methoxycarbonyl)amino]-3,3-dimethylbutanoic acid; Boc-L-tert-Leucine-OH (common misnomer, note different protecting group); N-Methoxycarbonyl-L-tert-leucine; (S)-2-(Methoxycarbonylamino)-3,3-dimethylbutyric acid; Fmoc-L-tert-Leucine-OH (common misnomer, note different protecting group)
EINECS	Contact for details

Quality Control

Our Methoxycarbonyl-L-tert-Leucine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.