Description

2-Nitro-4-(Trifluoromethyl)Benzyl Bromide is a versatile and high-value aromatic building block characterized by its reactive benzyl bromide and electron-withdrawing nitro and trifluoromethyl substituents. This compound is essential for the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research, where its unique structure facilitates the introduction of key functional groups. It is primarily sought after by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and advanced material sectors for constructing novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used to construct advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and polymers where its aromatic core and substituents modify electronic properties.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and target engagement.

Basic Information

Product Name	2-Nitro-4-(Trifluoromethyl)Benzyl Bromide
CAS No.	162333-02-0
Molecular Formula	C8H5BrF3NO2
Molecular Weight	284.03 g/mol
Synonyms	α-Bromo-2-nitro-4-(trifluoromethyl)toluene; 1-(Bromomethyl)-2-nitro-4-(trifluoromethyl)benzene; (2-Nitro-4-(trifluoromethyl)phenyl)methyl bromide; 4-(Trifluoromethyl)-2-nitrobenzyl bromide; 2-Nitro-α,α,α-trifluoro-p-tolyl bromide
EINECS	Contact for details

Quality Control

Our 2-Nitro-4-(Trifluoromethyl)Benzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.