Description

(S)-(R)-Josiphos CAS NO 162291-02-3 is a highly specialized, chiral ferrocenyl diphosphine ligand, a cornerstone in modern asymmetric catalysis. Its significance lies in its ability to induce high enantioselectivity and catalytic activity in a variety of transition metal-catalyzed reactions, enabling the efficient synthesis of single-enantiomer compounds. This product is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective hydrogenation of prochiral olefins, ketones, and imines, critical for producing chiral intermediates in active pharmaceutical ingredients (APIs).
• Pharmaceutical Synthesis: Used in the key catalytic steps for manufacturing enantiomerically pure drugs, including antibiotics, cardiovascular agents, and central nervous system therapeutics.
• Agrochemical Production: Enables the synthesis of chiral herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Fine Chemical Manufacturing: Applied in the production of specialty chemicals, flavors, fragrances, and advanced materials where high optical purity is required.
• Academic & Industrial R&D: A vital tool for developing new catalytic methodologies and exploring novel reaction pathways in asymmetric synthesis.
• Process Chemistry Optimization: Employed to scale up and optimize industrial catalytic processes for cost-effective and sustainable production of chiral molecules.

Basic Information

Item	Details
Product Name	(S)-(R)-Josiphos
CAS No.	162291-02-3
Molecular Formula	C31H32FeP2
Molecular Weight	522.36 g/mol
Synonyms	(R)-1-[(S)-2-(Diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine; (R)-(S)-PPF-PCy2; Josiphos SL-J009-1; Josiphos ligand; Ferrocenyl Josiphos ligand; (R)-1-[(S)-2-(Diphenylphosphino)ferrocenyl]ethyl(dicyclohexyl)phosphine; (R)-1-[(S)-2-(Diphenylphosphino)ferrocenyl]ethyldi(cyclohexyl)phosphine; (1R)-1-[(SP)-2-(Diphenylphosphanyl-kP)ferrocen-1-yl]ethyl(dicyclohexyl)phosphane
EINECS	Contact for details

Quality Control

Our (S)-(R)-Josiphos is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral assay, NMR for structural confirmation, and elemental analysis, to ensure it meets the high standards required for sensitive catalytic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Solubility	Soluble in common organic solvents (e.g., Toluene, DCM, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.