Description

Fibronectin Fragment (1377-1388) is a synthetic peptide fragment derived from the cell-binding domain of human fibronectin, a key glycoprotein in the extracellular matrix. This specific sequence, corresponding to residues 1377-1388, is crucial for mediating cell adhesion and signaling interactions. It is an essential research-grade biochemical for scientists in cell biology, oncology, and regenerative medicine. The product is supplied as a high-purity, lyophilized powder under the CAS registry number 162257-99-0.

Application

• Cell Adhesion & Migration Studies: Used as a coating substrate or soluble factor to investigate integrin-mediated cell attachment, spreading, and motility in vitro.
• Cancer Research: Employed to study tumor cell metastasis, angiogenesis, and the role of the extracellular matrix in tumor progression.
• Biomaterial & Tissue Engineering: Functionalizes surfaces of scaffolds and implants to enhance biocompatibility and promote specific cellular integration.
• Signal Transduction Pathways: Serves as a tool peptide to elucidate downstream signaling cascades activated by fibronectin-integrin binding.
• Inhibitor/Competitor Studies: Acts as a competitive inhibitor to block native fibronectin binding in functional assays.
• Antibody & Assay Development: Utilized as an antigen for generating and screening antibodies, or as a standard in ELISA and other immunoassays.

Basic Information

Product Name	Fibronectin Fragment (1377-1388)
CAS No.	162257-99-0
Molecular Formula	C58H94N18O19
Molecular Weight	1323.5 g/mol
Synonyms	Fibronectin Cell-Adhesion Peptide; Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro; RGDSPASSKPR; GRGDSP; Fibronectin (1377-1388) human; H-Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro-Arg-OH; Adhesion-promoting peptide; FN fragment (1377-1388)
EINECS	Contact for details

Quality Control

Our Fibronectin Fragment (1377-1388) is manufactured under strict quality systems to ensure batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. A Certificate of Analysis (COA) detailing purity, peptide content, and analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store the lyophilized powder at -20°C or below. For long-term storage, keep desiccated at -80°C. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.