Description

trans-2-Bocamino-Cyclopropanecarboxylic Acid Ethyl Ester is a high-value, protected cyclopropane amino acid derivative, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in providing a stereodefined, N-Boc-protected cyclopropane scaffold, which is essential for constructing complex molecules with precise three-dimensional architecture. This compound is indispensable for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and for use in medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, antiviral agents, and other bioactive molecules containing constrained cyclopropane motifs.
• Medicinal Chemistry: Used in lead optimization and structure-activity relationship (SAR) studies to introduce conformational rigidity and explore novel chemical space.
• Peptidomimetics: Serves as a non-natural amino acid analog for creating stable peptide mimics with enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Employed in the research and development of advanced pesticides and herbicides that utilize cyclopropane chemistry.
• Asymmetric Synthesis: A valuable starting material for catalytic asymmetric transformations to create enantiomerically pure compounds.
• Chemical Biology Probes: Used to develop tool compounds and molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	trans-2-Bocamino-Cyclopropanecarboxylic Acid Ethyl Ester
CAS No.	162129-60-4
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	Ethyl (1R,2S)-2-[(tert-Butoxycarbonyl)amino]cyclopropanecarboxylate; Ethyl trans-2-[(tert-Butoxycarbonyl)amino]cyclopropanecarboxylate; trans-N-Boc-2-Aminocyclopropanecarboxylic Acid Ethyl Ester; Boc-ACPC-OEt; (1R,2S)-2-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acid ethyl ester; Ethyl 2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopropanecarboxylate; trans-2-(Boc-amino)cyclopropanecarboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our trans-2-Bocamino-Cyclopropanecarboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.