Description

(S)-n-(2,2-Difluoroethylidene)-1-Phenylethylamine CAS NO 161754-60-5 is a chiral amine building block featuring a difluoroethylidene moiety, which is critical for imparting unique electronic and metabolic properties to target molecules. This compound is valued for its role as a key intermediate in the synthesis of advanced pharmaceutical agents, particularly in the development of enzyme inhibitors and receptor modulators. It is primarily sought by research institutions and pharmaceutical companies engaged in the discovery of new therapeutic entities, especially within the fields of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the synthesis of advanced crop protection agents and herbicides.
• Ligand Synthesis: Serves as a precursor for chiral ligands in asymmetric catalysis.
• Fluorinated Compound Libraries: A valuable component for creating diverse screening libraries in medicinal chemistry.
• Material Science Research: Investigated as a monomer or additive for specialty polymers with specific properties.

Basic Information

Product Name	(S)-n-(2,2-Difluoroethylidene)-1-Phenylethylamine
CAS No.	161754-60-5
Molecular Formula	C10H11F2N
Molecular Weight	183.20 g/mol
Synonyms	(S)-1-Phenylethyl-2,2-difluoroethylideneamine; (S)-α-Methylbenzyl-2,2-difluoroethylideneamine; (S)-N-(1-Phenylethylidene)-2,2-difluoroethanamine; (S)-N-(2,2-Difluoroethylidene)-α-methylbenzylamine; (S)-1-(2,2-Difluoroethylideneamino)-1-phenylethane; (S)-N-(2,2-Difluoroethylidene)-1-phenylethanamine
EINECS	Contact for details

Quality Control

Our (S)-n-(2,2-Difluoroethylidene)-1-Phenylethylamine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.