Description

5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylicacid,7-Amino-3-Methyl-,(6R-Trans)-(9Ci) is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key structural motif in the synthesis of novel β-lactam antibiotics and other biologically active molecules. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and antibiotic development.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of next-generation cephalosporin and carbapenem antibiotic candidates.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to develop new antimicrobial agents.
• Process Chemistry Development: Serves as a key starting material (KSM) or intermediate in the scale-up and optimization of API (Active Pharmaceutical Ingredient) manufacturing processes.
• Biochemical Research: Employed in studies investigating the mechanism of action and resistance of β-lactam antibiotics.
• Fine Chemical Synthesis: Utilized in the custom synthesis of complex, high-value molecules for specialized applications.

Basic Information

Product Name	5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylicacid,7-Amino-3-Methyl-,(6R-Trans)-(9Ci)
CAS No.	161742-21-8
Molecular Formula	C8H10N2O3S
Molecular Weight	214.24 g/mol
Synonyms	7-Amino-3-methyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R-trans)-7-Amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-ADCA derivative; 7-Amino-3-methylcephem-4-carboxylic acid; 7-Amino-3-methyl-δ³-cephem-4-carboxylic acid; 7-ACA related intermediate; 7-ADCA analog; 7-Amino-3-methyl-desacetoxycephalosporanic acid
EINECS	Contact for details

Quality Control

Our 5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylicacid,7-Amino-3-Methyl-,(6R-Trans)-(9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to verify identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.