Description

3,4-Difluorohydrocinnamic Acid is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the phenyl ring, which can dramatically influence the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoro motif can enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated monomers and compounds used in electronic displays and organic light-emitting diodes, improving charge transport and stability.
• Peptide Mimetics & Bio-conjugation: The carboxylic acid functionality allows for coupling to amines, making it useful for constructing peptide analogs or for linker chemistry in bioconjugation and probe development.
• Material Science Research: Employed as a monomer or cross-linking agent in the synthesis of specialty polymers with tailored properties like chemical resistance or specific optical characteristics.
• Chemical Biology Probes: Acts as a starting point for synthesizing fluorinated probes and tags used to study biological processes and enzyme mechanisms.

Basic Information

Product Name	3,4-Difluorohydrocinnamic Acid
CAS No.	161712-75-0
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	3-(3,4-Difluorophenyl)propanoic Acid; Benzenepropanoic acid, 3,4-difluoro-; 3,4-Difluorobenzene propanoic acid; 3,4-DFPA; 3,4-Difluoro-β-phenylpropionic Acid; 3,4-Difluorodihydrocinnamic Acid; (3,4-Difluorophenyl)propionic Acid
EINECS	Contact for details

Quality Control

Our 3,4-Difluorohydrocinnamic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from strong bases, oxidizing agents, and heat sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.