Description

1-n-Cbz-4-Cyanopiperidine is a versatile and high-purity chemical intermediate, specifically a protected piperidine derivative. Its value lies in providing a critical building block for the synthesis of complex pharmaceutical molecules and bioactive compounds. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for advanced synthetic routes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing piperidine scaffolds, such as kinase inhibitors, receptor antagonists, and central nervous system (CNS) drugs.
• Peptidomimetic Chemistry: Used to introduce the 4-cyanopiperidine moiety into peptide backbones to enhance metabolic stability, bioavailability, and binding affinity in drug discovery.
• Agrochemical Synthesis: Serves as a building block for developing novel herbicides, fungicides, and insecticides that incorporate nitrogen-containing heterocycles.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organocatalysts for asymmetric synthesis and transition metal catalysis.
• Chemical Biology Probes: Utilized to create labeled or tagged molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	1-n-Cbz-4-Cyanopiperidine
CAS No.	161609-84-3
Molecular Formula	C14H16N2O2
Molecular Weight	244.29 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-4-cyanopiperidine; 4-Cyano-1-Cbz-piperidine; 1-Carbobenzoxy-4-cyanopiperidine; 1-Cbz-4-cyanopiperidine; 1-N-Carbobenzyloxy-4-cyanopiperidine; 1-N-Cbz-4-cyanopiperidine; Piperidine, 4-cyano-1-[(phenylmethoxy)carbonyl]-; 4-Cyanopiperidine-1-carboxylic acid benzyl ester
EINECS	Contact for details

Quality Control

Our 1-n-Cbz-4-Cyanopiperidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support development and commercial projects requiring compliance with various pharmacopeial or internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.