Description

Benzonitrile, 4-[(Methylsulfonyl)Methyl]- is a high-purity, functionalized aromatic nitrile building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of a reactive nitrile group and a sulfone moiety, enabling its use as a versatile intermediate for constructing complex molecular architectures. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting kinase inhibition or requiring sulfone-containing pharmacophores.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its bifunctional reactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced polymers and functional organic materials with specific electronic or thermal properties.
• Chemical Biology Probes: Useful for synthesizing molecular probes to study enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CMOs for client-specific, multi-step synthetic projects requiring high-purity intermediates.

Basic Information

Product Name	Benzonitrile, 4-[(Methylsulfonyl)Methyl]-
CAS No.	161417-56-7
Molecular Formula	C9H9NO2S
Molecular Weight	195.24 g/mol
Synonyms	4-(Methylsulfonylmethyl)benzonitrile; p-[(Methylsulfonyl)methyl]benzonitrile; 4-(Methanesulfonylmethyl)benzonitrile; 1-Cyano-4-(methylsulfonylmethyl)benzene; (4-Cyanophenyl)methyl methyl sulfone; α-Toluenesulfonamide, 4-cyano-N-methyl-; Benzonitrile, 4-[(methylsulfonyl)methyl]- (9CI)
EINECS	Contact for details

Quality Control

Our Benzonitrile, 4-[(Methylsulfonyl)Methyl]- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.