Description

3-Methyl-2-Nitro-3H-Imidazo[4,5-F]Quinoline-2-14C is a carbon-14 labeled derivative of a complex heterocyclic compound, serving as a critical tool for advanced research and development. This labeled compound is essential for conducting precise metabolic, pharmacokinetic, and environmental fate studies where tracking the molecule is required. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on drug discovery and mechanistic toxicology.

Application

• Tracer Studies in Drug Metabolism and Pharmacokinetics (DMPK): Used to elucidate the absorption, distribution, metabolism, and excretion (ADME) profiles of lead compounds in preclinical development.
• Mechanistic Toxicology Research: Enables the investigation of bioactivation pathways and the formation of reactive metabolites that may cause toxicity.
• Environmental Fate and Degradation Studies: Tracks the transformation and persistence of chemical entities in ecological systems.
• Biochemical Pathway Analysis: Serves as a radiolabeled probe to study specific enzyme interactions and biochemical mechanisms.
• Reference Standard for Analytical Method Development: Used in LC-MS/MS and radio-HPLC methods to validate assays for quantifying the parent compound and its metabolites.

Basic Information

Product Name	3-Methyl-2-Nitro-3H-Imidazo[4,5-F]Quinoline-2-14C
CAS No.	161406-39-9
Molecular Formula	C₁₁H₇N₄O₂ (with 14C label at the 2-position)
Molecular Weight	~229.20 g/mol (exact mass depends on 14C enrichment)
Synonyms	2-Nitro-3-methyl-3H-imidazo[4,5-f]quinoline-2-14C; 3-Methyl-2-nitroimidazo(4,5-f)quinoline-2-14C; IQ-2-14C (labeled derivative); 2-Nitro-3-methylimidazo[4,5-f]quinoline-2-14C; 3-Methyl-2-nitro-3H-imidazo[4,5-f]quinoline-2-14C; Labeled Heterocyclic Amine; Radiolabeled IQ Derivative
EINECS	Contact for details

Quality Control

Every batch of our carbon-14 labeled compounds is produced and tested to meet the exacting standards required for research. Radiochemical purity and chemical purity are rigorously verified using a combination of analytical techniques including HPLC with radiometric detection. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specific activity, purity, and solvent information to ensure full traceability and compliance with your experimental protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures, typically between -20°C to -80°C for long-term stability of radiolabeled compounds, depending on the specific formulation and solvent. Follow all applicable radiation safety guidelines and regulations for handling and storage.

Specification

Item	Specification
Appearance	Solid (Color varies by batch)
Identification (HPLC, MS)	Conforms to structure
Chemical Purity (HPLC)	≥ 95%
Radiochemical Purity	≥ 97%
Specific Activity	Customizable (mCi/mmol)
Solvent	Specified per batch (e.g., Ethanol, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.