Description

Ethyl 3-[(2R)-2-[(2-Methoxyphenoxy)Methyl]Pyrrolidin-1-Yl]-3-Oxo-Propa Noate is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. Its core value lies in its role as a sophisticated building block for constructing complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and cardiovascular pathways. This compound is essential for research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, where precise stereochemistry and high chemical purity are non-negotiable requirements for efficacy and regulatory approval.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel central nervous system (CNS) active drugs and receptor modulators.
• API Development: Used in research and scale-up production of Active Pharmaceutical Ingredients (APIs) requiring a specific (R)-configured pyrrolidine moiety.
• Asymmetric Synthesis: Serves as a critical precursor in asymmetric catalytic processes to introduce stereogenic centers into complex molecular architectures.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies for new chemical entities.
• Pre-clinical & Clinical Trial Material: Supplied as a high-grade intermediate for producing batches intended for pre-clinical testing and clinical trial material (CTM) manufacturing.
• Contract Manufacturing (CMO): Sourced by contract manufacturing organizations for custom synthesis projects requiring this specific molecular fragment.

Basic Information

Product Name	Ethyl 3-[(2R)-2-[(2-Methoxyphenoxy)Methyl]Pyrrolidin-1-Yl]-3-Oxo-Propa Noate
CAS No.	161364-85-8
Molecular Formula	C18H25NO5
Molecular Weight	335.40 g/mol
Synonyms	Ethyl (R)-3-(2-((2-Methoxyphenoxy)methyl)pyrrolidin-1-yl)-3-oxopropanoate; (R)-Ethyl 3-(2-((2-Methoxyphenoxy)methyl)pyrrolidin-1-yl)-3-oxopropanoate; 3-Oxopropanoic acid, 3-[(2R)-2-[(2-methoxyphenoxy)methyl]-1-pyrrolidinyl]-, ethyl ester; UNII-9F6T8H8Y2T; 9F6T8H8Y2T; Ethyl 3-oxo-3-[(2R)-2-[(2-methoxyphenoxy)methyl]pyrrolidin-1-yl]propanoate; Propanoic acid, 3-[(2R)-2-[(2-methoxyphenoxy)methyl]-1-pyrrolidinyl]-3-oxo-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 3-[(2R)-2-[(2-Methoxyphenoxy)Methyl]Pyrrolidin-1-Yl]-3-Oxo-Propa Noate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and GMP-grade synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.