Description

Fmoc-Chg-Oh CAS NO 161321-36-4 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for the controlled introduction of the cyclohexylglycine (Chg) residue, a non-proteinogenic amino acid known for inducing specific conformational changes in peptide chains. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated, stepwise construction of custom peptide sequences.
• Pharmaceutical R&D: Used in the research and development of peptide-based drugs, where the incorporation of cyclohexylglycine can enhance metabolic stability, bioavailability, and target binding affinity.
• Peptidomimetic Design: Critical for creating peptide analogs and mimetics that mimic the function of natural peptides while improving pharmacological properties.
• Bioconjugation and Probe Synthesis: Employed in the synthesis of labeled peptides for diagnostic assays, imaging agents, and biochemical research tools.
• Academic Research: Used in university and institutional labs for studying protein-protein interactions, enzyme substrates, and structure-activity relationships (SAR).

Basic Information

Product Name	Fmoc-Chg-Oh
CAS No.	161321-36-4
Molecular Formula	C₂₄H₂₇NO₄
Molecular Weight	393.48 g/mol
Synonyms	Fmoc-cyclohexylglycine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]cyclohexylglycine; (R,S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-cyclohexylacetic acid; Fmoc-Cyclohexyl-Gly-OH; Fmoc-Chg-OH; N-Fmoc-cyclohexylglycine; 2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-cyclohexylacetic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Chg-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for pharmaceutical research. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity. A detailed Certificate of Analysis (COA) providing specifications for identity, assay, and related substances is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.