Description

n-Fmoc-Dl-Homoserine CAS NO 161125-35-5 is a protected, non-natural amino acid derivative widely used as a critical building block in solid-phase peptide synthesis (SPPS). Its value lies in providing a versatile homoserine residue with an orthogonal protecting group strategy, enabling the synthesis of complex peptides and peptidomimetics. This compound is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science who require high-purity intermediates for constructing novel therapeutic agents and bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of peptides containing homoserine.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based drugs, hormones, and enzyme inhibitors.
• Bioconjugation and Labeling: Serves as a handle for attaching fluorescent dyes, biotin, or other functional groups to peptides.
• Combinatorial Chemistry: Employed in libraries for drug discovery to explore structure-activity relationships.
• Glycopeptide Synthesis: Useful as a precursor for incorporating glycosylated amino acids into peptide chains.
• Material Science: Building block for creating peptide-based polymers and biomaterials with specific properties.

Basic Information

Product Name	n-Fmoc-Dl-Homoserine
CAS No.	161125-35-5
Molecular Formula	C20H21NO5
Molecular Weight	355.39 g/mol
Synonyms	Fmoc-DL-homoserine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-DL-homoserine; DL-Homoserine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-hydroxybutanoic acid; Fmoc-Hse-OH; Fmoc-DL-Hse-OH; N-Fmoc-DL-homoserine; 2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-4-hydroxybutanoic acid
EINECS	Contact for details

Quality Control

Our n-Fmoc-Dl-Homoserine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Optical Purity (Chiral HPLC)	DL-mixture (Racemic)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.