Description

Cyclohexanecarbonyl Fluoride, 2-(Trifluoromethyl)-, cis- (9Ci) CAS NO 161117-11-9 is a high-purity, fluorinated organic building block characterized by its unique cis-configured cyclohexane ring. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where its specific stereochemistry and fluorine atoms are essential for bioactivity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the trifluoromethyl group enhances lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Serves as a fluorinated precursor for electronic chemicals used in display technologies.
• Advanced Polymer Modification: Employed to introduce fluorine-containing side chains into polymers to alter surface properties, chemical resistance, and stability.
• Organic Synthesis & Catalysis: A versatile reagent in academic and industrial research for exploring new fluorination methodologies and asymmetric synthesis.
• Positron Emission Tomography (PET) Tracer Development: Potential use as a precursor for fluorine-18 labeled radiopharmaceuticals for medical imaging.

Basic Information

Product Name	Cyclohexanecarbonyl Fluoride, 2-(Trifluoromethyl)-, cis- (9Ci)
CAS No.	161117-11-9
Molecular Formula	C8H10F4O
Molecular Weight	198.16 g/mol
Synonyms	cis-2-(Trifluoromethyl)cyclohexanecarbonyl fluoride; (1R,2S)-2-(Trifluoromethyl)cyclohexane-1-carbonyl fluoride; 2-(Trifluoromethyl)cyclohexanecarboxylic acid fluoride, cis-; cis-2-(Trifluoromethyl)cyclohexanoyl fluoride; Fluorocarbonyl-2-(trifluoromethyl)cyclohexane, cis-; 161117-11-9; cis-2-Trifluoromethylcyclohexanecarbonyl fluoride
EINECS	Contact for details

Quality Control

Our Cyclohexanecarbonyl Fluoride, 2-(Trifluoromethyl)-, cis- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (cis-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.