Description

1,2-Cyclohexanedicarbonyl Difluoride, trans- (9Ci) is a high-purity, specialized fluorinated building block used in advanced organic synthesis. Its value lies in its role as a key precursor for introducing the difluoromethylene moiety, a critical structural element in modern pharmaceuticals and agrochemicals. This compound is essential for researchers and process chemists in pharmaceutical R&D, agrochemical development, and material science who require reliable, high-quality intermediates for constructing complex molecules. Its defined stereochemistry and functional group reactivity make it a valuable tool for targeted molecular design.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated segments to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where fluorination improves efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the production of specialty polymers and advanced materials with unique thermal or chemical resistance.
• Ligand and Catalyst Development: Employed in the creation of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new C-F bond formation methodologies and fluorinated compound libraries.
• Liquid Crystal and Electronic Material Synthesis: Used in the preparation of fluorinated components for display technologies and electronic coatings.

Basic Information

Product Name	1,2-Cyclohexanedicarbonyl Difluoride, trans- (9Ci)
CAS No.	161117-10-8
Molecular Formula	C8H10F2O2
Molecular Weight	176.16 g/mol
Synonyms	trans-1,2-Cyclohexanedicarboxylic Acid Difluoride; trans-Hexahydrophthaloyl Difluoride; (1R,2R)-Cyclohexane-1,2-dicarbonyl Difluoride; (1S,2S)-Cyclohexane-1,2-dicarbonyl Difluoride; Cyclohexane-1,2-dicarboxylic Acid Difluoride, trans-; 1,2-Cyclohexanedicarboxylic Acid, trans-, Difluoride; Hexahydroisophthaloyl Difluoride, trans-; 1,2-trans-Cyclohexanedicarbonyl Difluoride
EINECS	Contact for details

Quality Control

Our 1,2-Cyclohexanedicarbonyl Difluoride, trans- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chromatography (HPLC/GC) and spectroscopic methods (NMR, IR), to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Trans Isomer Content (GC/HPLC)	≥ 98.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.