Description

Cyclohexanecarbonyl Fluoride, 2-(Trifluoromethyl)-, trans- (9Ci) is a high-value fluorinated building block characterized by its trans-cyclohexane ring and reactive acyl fluoride functional group. This compound is essential for introducing the 2-(trifluoromethyl)cyclohexanecarbonyl moiety into advanced molecular architectures, enabling the fine-tuning of physical and chemical properties. It is primarily sought by R&D and process chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting metabolic diseases and CNS disorders.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a critical intermediate for fluorinated compounds used in electronic display technologies.
• Advanced Polymer Modification: Employed to introduce fluorinated cyclohexyl groups into polymer backbones, improving thermal stability and chemical resistance.
• Organic Synthesis Reagent: The acyl fluoride group acts as a highly reactive acylating agent in peptide coupling and esterification reactions under mild conditions.
• Fluorine Chemistry Research: A valuable substrate for studying stereoselective reactions and the influence of the trans-cyclohexane conformation on reactivity.

Basic Information

Product Name	Cyclohexanecarbonyl Fluoride, 2-(Trifluoromethyl)-, trans- (9Ci)
CAS No.	161117-09-5
Molecular Formula	C8H10F4O
Molecular Weight	198.16 g/mol
Synonyms	trans-2-(Trifluoromethyl)cyclohexanecarbonyl fluoride; (1r,2r)-2-(Trifluoromethyl)cyclohexane-1-carbonyl fluoride; 2-(Trifluoromethyl)cyclohexanecarboxylic acid fluoride, trans-; trans-2-(Trifluoromethyl)cyclohexanoyl fluoride; (trans)-2-(Trifluoromethyl)cyclohexanecarbonyl fluoride; Fluorocarbonyl-trans-2-(trifluoromethyl)cyclohexane; Cyclohexanecarboxylic acid, 2-(trifluoromethyl)-, fluoride, trans-
EINECS	Contact for details

Quality Control

Our Cyclohexanecarbonyl Fluoride, 2-(Trifluoromethyl)-, trans- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality system is designed to support cGMP compliance for pharmaceutical development, and we can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.0%
Isomeric Purity (trans-)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.