Description

2-Butanone, 4,4,4-Trifluoro-3-Hydroxy- (9Ci) is a fluorinated hydroxy ketone building block of significant interest in advanced organic synthesis. This compound matters for its unique trifluoromethyl and hydroxyl functional groups, which are critical for modulating the physicochemical properties of target molecules. It is primarily needed by pharmaceutical, agrochemical, and specialty chemical R&D teams for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of fluorinated drug candidates, particularly for CNS and metabolic disease targets.
• Agrochemical Synthesis: Used in creating novel fluorinated pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials, contributing to improved performance and durability.
• Advanced Polymer Modification: Incorporated into specialty polymers to impart unique surface properties, chemical resistance, and thermal stability.
• Asymmetric Catalysis & Ligand Development: Utilized as a chiral pool reagent or precursor for synthesizing novel ligands and catalysts in enantioselective synthesis.
• Fluorine-19 NMR Spectroscopy: Can be employed as a reference standard or probe molecule in analytical chemistry and metabolic studies.

Basic Information

Product Name	2-Butanone, 4,4,4-Trifluoro-3-Hydroxy- (9Ci)
CAS No.	161084-29-3
Molecular Formula	C4H5F3O2
Molecular Weight	142.08 g/mol
Synonyms	4,4,4-Trifluoro-3-hydroxybutan-2-one; 3-Hydroxy-4,4,4-trifluorobutan-2-one; 1,1,1-Trifluoro-3-hydroxy-2-butanone; 4,4,4-Trifluoro-3-hydroxy-2-butanone; 3-Hydroxy-4,4,4-trifluoro-2-butanone; TFHB; Trifluorohydroxybutanone
EINECS	Contact for details

Quality Control

Our 2-Butanone, 4,4,4-Trifluoro-3-Hydroxy- (9Ci) is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.