Description

N1-Acetylsulfamethoxazol CAS NO 161055-47-6 is a key pharmaceutical intermediate, specifically an acetylated derivative of the sulfonamide antibiotic sulfamethoxazole. This compound is of critical importance in the synthesis and research of advanced antimicrobial agents, serving as a vital building block for developing new therapeutic molecules. It is primarily required by manufacturers and research institutions in the pharmaceutical, biotechnology, and fine chemical sectors engaged in antibiotic development and process chemistry.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of sulfonamide-based antibiotic compounds and their derivatives.
• Active Pharmaceutical Ingredient (API) Research: Used in the research and development of new antimicrobial agents targeting bacterial dihydropteroate synthase.
• Metabolite Studies: Serves as a reference standard or metabolite in pharmacokinetic and pharmacodynamic studies of sulfamethoxazole.
• Process Chemistry: Employed in scaling up and optimizing manufacturing routes for complex sulfonamide drugs.
• Analytical Standard: Used as a high-purity standard in quality control (QC) and analytical method development (e.g., HPLC, LC-MS).

Basic Information

Product Name	N1-Acetylsulfamethoxazol
CAS No.	161055-47-6
Molecular Formula	C13H14N4O4S
Molecular Weight	322.34 g/mol
Synonyms	N1-Acetylsulfamethoxazole; 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide, N1-acetyl derivative; N1-Acetylsulfamethoxazole; N-Acetylsulfamethoxazole; Sulfamethoxazole Impurity C (Acetyl); 1-Acetylsulfamethoxazole; Acetylsulfamethoxazole; SMX Acetyl Derivative
EINECS	Contact for details

Quality Control

Our N1-Acetylsulfamethoxazol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product undergoes rigorous analytical testing, including HPLC for assay and related substances, to meet exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.