Description

Levofloxacin Acyl-β-D-Glucuronide is a key metabolite and reference standard of the broad-spectrum fluoroquinolone antibiotic, levofloxacin. This compound is essential for advanced pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily utilized by research institutions, pharmaceutical manufacturers, and contract research organizations (CROs) engaged in drug discovery and regulatory compliance activities.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantification and identification of levofloxacin metabolites in biological matrices during clinical and preclinical studies.
• Drug Metabolism and Pharmacokinetics (DMPK) Research: Critical for investigating the metabolic pathways, clearance mechanisms, and bioavailability of levofloxacin.
• Bioanalytical Method Development: Used to develop and validate sensitive HPLC, LC-MS, or LC-MS/MS methods for therapeutic drug monitoring and pharmacokinetic assays.
• Impurity Profiling and Characterization: Employed as a known impurity or degradation product to ensure the purity and stability of levofloxacin active pharmaceutical ingredient (API) formulations.
• Toxicology and Safety Assessment: Aids in the safety evaluation of levofloxacin by characterizing its metabolite profile and potential interactions.

Basic Information

Product Name	Levofloxacin Acyl-β-D-Glucuronide
CAS No.	160962-46-9
Molecular Formula	C25H30FNO12
Molecular Weight	555.51 g/mol
Synonyms	Levofloxacin Glucuronide; (S)-Levofloxacin Acyl-β-D-Glucuronide; Levofloxacin Acyl Glucuronide; 9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid β-D-glucopyranosiduronic acid ester; Levofloxacin metabolite; DR-3355 Glucuronide
EINECS	Contact for details

Quality Control

Our Levofloxacin Acyl-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. Due to its hygroscopic (moisture-sensitive) nature, the container should be sealed under an inert atmosphere after each use to prevent degradation. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.