Description

n-Fmoc-Dl-Isovaline is a protected, non-proteinogenic amino acid derivative, specifically the N-fluorenylmethyloxycarbonyl (Fmoc) derivative of racemic isovaline. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of the unique isovaline structure into peptide chains. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and bioactive molecules for therapeutic and diagnostic applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected amino acid for the automated synthesis of custom peptides containing the isovaline moiety.
• Peptidomimetic Research: Used to introduce structural constraints and modify peptide backbones to enhance stability, bioavailability, and biological activity.
• Medicinal Chemistry: A vital intermediate in the research and development of new peptide-based pharmaceuticals and drug candidates.
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR) of peptides and the role of non-standard amino acids.
• Antibiotic & Antimicrobial Peptide Development: Used to synthesize analogs of natural peptides with potential antimicrobial properties.
• Material Science: Can be incorporated into peptide-based polymers and biomaterials for specialized applications.

Basic Information

Product Name	n-Fmoc-Dl-Isovaline
CAS No.	160885-93-8
Molecular Formula	C₂₁H₂₁NO₅
Molecular Weight	367.40 g/mol
Synonyms	Fmoc-DL-isovaline; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-DL-isovaline; (RS)-2-Amino-2-methylbutanoic acid N-Fmoc derivative; DL-Isovaline, N-Fmoc-; N-Fluorenylmethoxycarbonyl-DL-isovaline; Fmoc-DL-Iva-OH; 2-Methyl-2-[(9H-fluoren-9-ylmethoxy)formamido]butanoic acid; N-α-Fmoc-DL-isovaline
EINECS	Contact for details

Quality Control

Our n-Fmoc-Dl-Isovaline is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports applications in GMP-like environments for non-clinical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	Racemic mixture (DL)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.