Description

Mono-6-n-Diboc-Guanyl-1,6-Hexadiamine CAS NO 160677-41-8 is a high-purity, protected guanidine derivative used as a critical building block in advanced organic synthesis. Its primary value lies in enabling the controlled introduction of guanidine functional groups, which are essential for creating compounds with specific biological activity. This intermediate is particularly vital for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel therapeutics, including protease inhibitors and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of guanidine-containing drug candidates, such as protease inhibitors and antiviral agents.
• Peptidomimetic Chemistry: Used in the construction of peptide analogs where the guanidine group mimics arginine side chains for enhanced binding affinity.
• Bioconjugation & Linker Chemistry: Serves as a functional handle for attaching labels, probes, or other molecules to biomolecules or surfaces.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by providing a protected route to incorporate guanidine motifs into lead compounds.
• Solid-Phase Peptide Synthesis (SPPS): Employed as a Boc-protected diamine linker or building block for the assembly of complex peptides on resin.
• Chemical Biology Tool Development: Facilitates the creation of chemical probes for studying enzyme function and protein-protein interactions.

Basic Information

Product Name	Mono-6-n-Diboc-Guanyl-1,6-Hexadiamine
CAS No.	160677-41-8
Molecular Formula	C₂₀H₄₀N₆O₄
Molecular Weight	428.57 g/mol
Synonyms	1,6-Hexanediamine, N6-[bis[(1,1-dimethylethoxy)carbonyl]amino]-; N6-Bis(tert-butoxycarbonyl)guanyl-1,6-hexanediamine; 6-[Bis(tert-butoxycarbonyl)amino]-1-guanylhexane; N6-(Di-Boc-guanyl)-1,6-diaminohexane; Mono-6-N-(Di-Boc-guanyl)-1,6-hexanediamine; Boc-Guanyl(Boc)-Ahx-NH₂; (6-Aminohexyl)guanidine, N,N''-bis-Boc protected; Di-Boc-guanyl-hexamethylenediamine
EINECS	Contact for details

Quality Control

Our Mono-6-n-Diboc-Guanyl-1,6-Hexadiamine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.