Description

4-(Trifluoromethoxy)Phenylacetylene is a high-value aromatic acetylene derivative featuring a trifluoromethoxy substituent. This compound is a critical building block in advanced organic synthesis, prized for its ability to introduce both the rigid acetylene linkage and the electron-withdrawing, lipophilic trifluoromethoxy group into target molecules. It is primarily utilized by pharmaceutical and agrochemical research and development teams, as well as material scientists, for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of bioactive molecules, including kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides with enhanced efficacy and environmental profiles.
• Material Science: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Sonogashira, Heck, and other palladium-catalyzed coupling reactions to form complex conjugated systems.
• Ligand Preparation: Used to synthesize acetylene-based ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: A valuable reagent for studying the effects of the trifluoromethoxy group on molecular properties and reactivity.

Basic Information

Product Name	4-(Trifluoromethoxy)Phenylacetylene
CAS No.	160542-02-9
Molecular Formula	C9H5F3O
Molecular Weight	186.13 g/mol
Synonyms	1-Ethynyl-4-(trifluoromethoxy)benzene; 4-Ethynylphenyl trifluoromethyl ether; p-(Trifluoromethoxy)phenylacetylene; 4-(Trifluoromethoxy)benzenecarbaldehyde; (4-(Trifluoromethoxy)phenyl)ethyne
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethoxy)Phenylacetylene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.