Description

Osanetant CAS NO 160492-56-8 is a potent and selective neurokinin 3 (NK3) receptor antagonist. This compound is of significant interest in pharmaceutical research and development for its potential to modulate neuroendocrine pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics for central nervous system disorders and endocrine-related conditions.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) in preclinical and clinical studies targeting NK3 receptors.
• Neurokinin Receptor Studies: Used as a selective tool compound in pharmacological assays to investigate the role of the NK3 receptor in various physiological and pathological processes.
• Drug Discovery Programs: Integral to medicinal chemistry efforts aimed at developing new treatments for conditions such as schizophrenia, menopausal symptoms, and other neuropsychiatric disorders.
• Biochemical Screening: Employed in high-throughput screening (HTS) platforms to identify and validate new drug candidates interacting with neurokinin pathways.
• Academic Research: Utilized in university and institutional labs for basic science research into neurotransmission and hormone regulation.
• GMP Manufacturing: Sourced as a starting material or intermediate for the cGMP-compliant synthesis of investigational new drugs (INDs).

Basic Information

Product Name	Osanetant
CAS No.	160492-56-8
Molecular Formula	C₂₃H₂₉N₃O₃
Molecular Weight	395.50 g/mol
Synonyms	SR 142801; (R)-N-(1-(3-(1-Benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl)propyl)-4-phenylpiperidin-4-yl)-N-methylacetamide; Osanetant [INN]; SR-142801; UNII-6U5L8E8Q7H; 6U5L8E8Q7H; (R)-Osanetant; NK3 Receptor Antagonist SR142801
EINECS	Contact for details

Quality Control

Every batch of Osanetant is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, supporting regulatory submissions for research and development. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data (including HPLC, NMR, and MS) are available for all shipments. Our quality commitment aligns with the standards expected for pharmaceutical reference materials and intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.