Description

Fmoc-His-Ome is a protected derivative of the amino acid L-Histidine, specifically designed for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the controlled and efficient assembly of complex peptides, particularly those containing the histidine residue. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for peptide-based drug discovery and development. The product is supplied as a high-quality reagent to ensure optimal coupling efficiency and minimal side reactions during synthesis.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid derivative for the automated or manual synthesis of peptides.
• Pharmaceutical Research: Used in the development and production of peptide-based active pharmaceutical ingredients (APIs) and therapeutic candidates.
• Bioconjugation: Serves as a precursor for creating histidine-tagged molecules or for site-specific modifications in protein engineering.
• Combinatorial Chemistry: A valuable building block in libraries for high-throughput screening of bioactive peptides.
• Academic & Industrial R&D: Fundamental reagent for studying peptide structure, function, and interactions in biochemical research.

Basic Information

Product Name	Fmoc-His-Ome
CAS No.	160450-10-2
Molecular Formula	C₂₂H₂₃N₃O₅
Molecular Weight	409.44 g/mol
Synonyms	Fmoc-L-histidine methyl ester; Fmoc-His-OMe; N-(9-Fluorenylmethoxycarbonyl)-L-histidine methyl ester; (S)-Methyl 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-imidazol-4-yl)propanoate; FMOC-HIS-OME; FMOC-HISTIDINE METHYL ESTER; FMOC-HIS-OMETHYL ESTER; FMOC-HIS(OME)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-His-Ome is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment, chiral analysis to confirm enantiomeric purity, and identity confirmation by spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.