Description

Fmoc-n-ω-Nitro-D-Arginine CAS NO 160347-94-4 is a protected, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This high-purity building block is critical for researchers and manufacturers developing novel peptide-based pharmaceuticals and biochemical tools. It is primarily utilized in solid-phase peptide synthesis (SPPS) by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on creating peptides with enhanced stability and specific biological activity.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the controlled, sequential assembly of complex peptide chains, particularly those requiring D-arginine analogs.
• Pharmaceutical Research & Development: Used in the discovery and development of novel therapeutic peptides, including enzyme inhibitors, receptor agonists/antagonists, and antimicrobial agents.
• Peptidomimetic Design: Incorporation into peptide backbones to create analogs with improved metabolic stability, bioavailability, and target specificity.
• Bioconjugation and Probe Development: Serves as a functional handle for attaching labels, tags, or other molecules to peptides for diagnostic or imaging applications.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse libraries of peptide compounds for high-throughput screening against biological targets.
• Biochemical Research: Employed in studies of protein-protein interactions, signal transduction pathways, and enzyme mechanisms where modified arginine residues are required.

Basic Information

Product Name	Fmoc-n-ω-Nitro-D-Arginine
CAS No.	160347-94-4
Molecular Formula	C₂₂H₂₆N₆O₆
Molecular Weight	470.48 g/mol
Synonyms	Fmoc-D-Arg(NO₂)-OH; N-α-Fmoc-N-ω-nitro-D-arginine; Fmoc-N-ω-nitro-D-arginine; (2R)-5-[(Nitroamino)imino]-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]pentanoic acid; D-Fmoc-Arg(NO₂)-OH; Fmoc-D-N-ω-nitroarginine; N-α-(9-Fluorenylmethyloxycarbonyl)-N-ω-nitro-D-arginine; Fmoc-D-Arg(NO2)-OH
EINECS	Contact for details

Quality Control

Every batch of Fmoc-n-ω-Nitro-D-Arginine is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for sensitive peptide synthesis. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity (by HPLC), chiral purity, and identity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light may lead to decomposition and reduced performance. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.