Description

Normeperidine-D4 is a high-purity, deuterium-labeled internal standard essential for precise quantitative analysis in modern analytical laboratories. This stable isotope-labeled compound is critical for ensuring accuracy and reliability in mass spectrometry-based methods, particularly when analyzing its non-deuterated counterpart. It is primarily utilized by pharmaceutical researchers, forensic toxicologists, and contract research organizations (CROs) engaged in method development, pharmacokinetic studies, and substance verification.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound for the accurate quantification of normeperidine in complex biological matrices such as plasma, serum, and urine.
• Pharmaceutical Research & Development: Used in metabolism studies, pharmacokinetic (PK) profiling, and bioanalytical method validation for meperidine (pethidine) and its metabolites.
• Forensic Toxicology: Enables precise and legally defensible analysis in workplace drug testing, post-mortem investigations, and clinical toxicology reports.
• Reference Material Manufacturing: Acts as a certified component in the production of calibrated reference standards and quality control materials for clinical laboratories.
• Doping Control Analysis: Employed in sports anti-doping programs to detect and confirm the presence of prohibited synthetic opioids.
• Academic Research: Supports studies in neuropharmacology, analgesic metabolism, and the development of novel analytical techniques in university and institutional labs.

Basic Information

Product Name	Normeperidine-D4
CAS No.	160227-47-4
Molecular Formula	C15H17D4NO2
Molecular Weight	251.36 g/mol (calculated)
Synonyms	1-Methyl-4-phenyl-4-piperidinecarboxylic Acid-d4 Ethyl Ester; Pethidine-d4 Impurity A; Norpethidine-d4; Desmethylmeperidine-d4; 4-Carbethoxypiperidine-d4; Ethyl 1-methyl-4-phenylisonipecotate-d4; Ethyl 4-phenyl-1-methylpiperidine-4-carboxylate-d4; Meperidine-d4 Related Compound A
EINECS	Contact for details

Quality Control

Every batch of Normeperidine-D4 is manufactured and analyzed under strict quality management protocols to ensure the highest isotopic purity and chemical integrity. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with the stringent requirements for analytical reference standards. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D4), chemical purity, and analytical results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D4)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.