Description

Irbesartan n--D-Glucuronide is a key metabolite of the antihypertensive drug Irbesartan, formed via glucuronidation. This compound is of significant importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of bioanalytical methods. It is primarily needed by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in metabolite identification, ADME (Absorption, Distribution, Metabolism, and Excretion) studies, and the production of reference standards.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the qualitative and quantitative analysis of Irbesartan and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Critical for investigating the metabolic pathways, clearance mechanisms, and bioavailability of Irbesartan in preclinical and clinical research.
• Bioanalytical Method Development: Used as a standard to develop and validate sensitive HPLC, LC-MS, or LC-MS/MS methods for therapeutic drug monitoring and pharmacokinetic profiling.
• Impurity Profiling: Employed in the identification and quantification of process-related or degradation impurities in Irbesartan active pharmaceutical ingredient (API) and finished dosage forms.
• Toxicology and Safety Assessment: Aids in understanding the safety profile of Irbesartan by characterizing its major human metabolites.

Basic Information

Product Name	Irbesartan n--D-Glucuronide
CAS No.	160205-58-3
Molecular Formula	C33H41N7O9
Molecular Weight	679.73 g/mol
Synonyms	Irbesartan Glucuronide; Irbesartan D-Glucuronide; Irbesartan Metabolite; 2-Butyl-3-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1,3-diazaspiro[4.4]non-1-en-4-one Glucuronide; BMS-186295 Glucuronide; SR 47436 Glucuronide; Aprovel Metabolite; Karvea Metabolite
EINECS	Contact for details

Quality Control

Our Irbesartan n--D-Glucuronide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) providing detailed results from identity, purity, and impurity profile testing conducted via advanced analytical techniques such as HPLC, LC-MS, and NMR. We adhere to relevant industry standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.