Description

L-Proline, 3-Hydroxy-, Hydrochloride (1:1), (3R)- is a high-purity, non-proteinogenic amino acid derivative, specifically the hydrochloride salt of (3R)-3-hydroxy-L-proline. This compound is a critical chiral building block and intermediate in advanced organic synthesis and pharmaceutical research. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries developing novel therapeutics, peptide-based drugs, and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, including protease inhibitors and other biologically active molecules.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate the 3-hydroxyproline residue, which can influence peptide conformation and stability.
• Biochemical Research: Serves as a standard or reagent in enzymatic studies, metabolic pathway analysis, and collagen research due to its role as a modified amino acid.
• Asymmetric Catalysis: Employed as a precursor or ligand in the development of chiral catalysts for stereoselective chemical transformations.
• Cosmetic & Nutraceutical R&D: Investigated for potential applications in formulations targeting skin health and collagen production.

Basic Information

Product Name	L-Proline, 3-Hydroxy-, Hydrochloride (1:1), (3R)-
CAS No.	159830-97-4
Molecular Formula	C5H10ClNO3
Molecular Weight	167.59 g/mol
Synonyms	(3R)-3-Hydroxy-L-proline hydrochloride; (2S,3R)-3-Hydroxypyrrolidine-2-carboxylic acid hydrochloride; trans-3-Hydroxy-L-proline hydrochloride; 3(R)-Hydroxy-L-proline HCl; L-3-Hydroxyproline hydrochloride; (3R)-Hydroxyproline HCl; Hydroxyproline HCl (specifically the 3R isomer); cis-4-Hydroxy-D-proline hydrochloride (isomeric distinction)
EINECS	Contact for details

Quality Control

Our L-Proline, 3-Hydroxy-, Hydrochloride (1:1), (3R)- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (3R)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.