Description

Fmoc-Aad(Otbu)-Oh CAS NO 159751-47-0 is a protected amino acid derivative, specifically an Fmoc-protected 2-aminoadipic acid with a tert-butyl ester side chain, essential for solid-phase peptide synthesis (SPPS). This building block is critical for researchers and manufacturers requiring high-purity intermediates to construct complex peptides with specific structural motifs. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and CROs engaged in the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the automated synthesis of custom peptides.
• Pharmaceutical Research: Intermediate in the development of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs).
• Bioconjugation: Used to introduce the 2-aminoadipic acid moiety into proteins or other biomolecules for linker or labeling applications.
• Combinatorial Chemistry: A valuable scaffold for generating diverse chemical libraries in drug discovery programs.
• Biochemical Tool Development: Synthesis of enzyme substrates, inhibitors, or probes containing modified amino acid structures.
• Academic Research: Fundamental studies in peptide chemistry, structure-activity relationships (SAR), and molecular biology.

Basic Information

Product Name	Fmoc-Aad(Otbu)-Oh
CAS No.	159751-47-0
Molecular Formula	C26H31NO6
Molecular Weight	453.53 g/mol
Synonyms	Fmoc-2-Aad(OtBu)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-2-aminoadipic acid 6-tert-butyl ester; Fmoc-L-2-aminoadipic acid 6-tert-butyl ester; (2S)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}hexanedioic acid 6-tert-butyl ester; Fmoc-Aad(OtBu)-OH; Fmoc-2-Aminoadipic acid(OtBu)-OH; N-α-Fmoc-L-2-aminoadipic acid 6-tert-butyl ester; Fmoc-α-Aad(OtBu)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Aad(Otbu)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive peptide synthesis applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.