Description

(S)-2-(Benzylamino)-2-(4-Fluorophenyl)Acetic Acid CAS NO 159707-18-3 is a high-value, non-natural amino acid derivative featuring a chiral center and a fluorinated aromatic ring. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the development of molecules with specific stereochemistry and enhanced biological activity. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of active pharmaceutical ingredients (APIs), peptide mimetics, and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs), particularly in therapeutic areas targeting the central nervous system.
• Peptidomimetic Chemistry: Used to incorporate non-natural amino acid motifs into peptide chains to enhance stability, bioavailability, and receptor binding affinity.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in catalytic asymmetric reactions to construct complex molecules with high enantiomeric purity.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies and high-throughput screening libraries to discover new drug candidates.
• Agrochemical Synthesis: Potential intermediate in the development of advanced, fluorinated agrochemicals with improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Can be utilized to synthesize novel chiral ligands for metal-catalyzed reactions or organocatalysts.

Basic Information

Product Name	(S)-2-(Benzylamino)-2-(4-Fluorophenyl)Acetic Acid
CAS No.	159707-18-3
Molecular Formula	C15H14FNO2
Molecular Weight	259.28 g/mol
Synonyms	(S)-2-(Benzylamino)-2-(4-fluorophenyl)acetic acid; (S)-α-(Benzylamino)-4-fluorobenzeneacetic acid; (S)-N-Benzyl-2-amino-2-(4-fluorophenyl)acetic acid; (S)-2-Amino-2-(4-fluorophenyl)-N-(phenylmethyl)acetamide precursor; 4-Fluoro-DL-phenylglycine benzylamide acid; (S)-N-Benzyl-4-fluorophenylglycine; (S)-Benzyl-(4-fluorophenyl)glycine; (S)-2-(4-Fluorophenyl)-2-(benzylamino)ethanoic acid
EINECS	Contact for details

Quality Control

Our production of (S)-2-(Benzylamino)-2-(4-Fluorophenyl)Acetic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is subjected to comprehensive analytical testing, including HPLC for chiral purity and assay, 1H/13C NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting identity, purity (typically ≥97% by HPLC), enantiomeric excess (ee), and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.