Description

Bradykinin, 4-Iodo-Phe(5)- is a chemically modified peptide analog of the endogenous vasoactive nonapeptide bradykinin. This compound is of significant value in biochemical and pharmacological research due to its role as a potent, selective ligand for studying bradykinin B2 receptor signaling pathways and function. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in cardiovascular research, inflammation studies, and neuropeptide signaling.

Application

• Pharmacological Research: Used as a key tool compound for investigating the physiological and pathological roles of the bradykinin B2 receptor.
• Drug Discovery & Development: Serves as a reference standard and a starting point for designing novel receptor agonists or antagonists targeting cardiovascular and inflammatory diseases.
• Biochemical Assays: Employed in competitive binding assays, receptor activation studies, and signal transduction pathway analysis.
• Academic Research: Facilitates fundamental studies in vascular biology, pain perception, and the kinin-kallikrein system.
• Diagnostic Development: Potential use in the development of diagnostic kits or assays for conditions related to bradykinin dysregulation.

Basic Information

Product Name	Bradykinin, 4-Iodo-Phe(5)-
CAS No.	159694-13-0
Molecular Formula	C50H73N15O11I
Molecular Weight	~1244.1 g/mol
Synonyms	4-Iodo-Phe(5)-Bradykinin; [Phe5(4-I)]-Bradykinin; H-Arg-Pro-Pro-Gly-Phe(4-I)-Ser-Pro-Phe-Arg-OH; Iodo-Bradykinin; Bradykinin B2 Receptor Ligand; BK (4-I-Phe5); Kallidin I analog
EINECS	Contact for details

Quality Control

Our Bradykinin, 4-Iodo-Phe(5)- is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. We provide Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues, ensuring compliance with research-grade standards. Custom synthesis to specific purity levels (e.g., >95%, >98%) is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.