Description

3-(Trifluoromethoxy)Benzyl Bromide is a versatile and high-value organobromide building block characterized by its reactive benzyl bromide group and electron-withdrawing trifluoromethoxy substituent. This compound matters for its critical role in facilitating efficient carbon-carbon and carbon-heteroatom bond formation, enabling the synthesis of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing active pharmaceutical ingredients (APIs), crop protection agents, and functional chemical intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry for creating libraries of compounds with potential biological activity.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group can enhance metabolic stability and lipophilicity.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized phosphine ligands or other functional molecules used in catalytic processes.
• Material Science Research: Employed in the creation of monomers or functionalized polymers with specific electronic or surface properties.
• Cross-Coupling Reactions: An effective electrophile in palladium-catalyzed reactions like Suzuki, Heck, or Buchwald-Hartwig amination for constructing biaryl and other complex structures.
• Nucleophilic Substitution: The benzyl bromide moiety readily undergoes substitution with various nucleophiles (amines, thiols, alkoxides) to introduce new functional groups.

Basic Information

Product Name	3-(Trifluoromethoxy)Benzyl Bromide
CAS No.	159689-88-0
Molecular Formula	C8H6BrF3O
Molecular Weight	255.04 g/mol
Synonyms	α-Bromo-3-(trifluoromethoxy)toluene; (3-(Trifluoromethoxy)phenyl)methyl bromide; 1-(Bromomethyl)-3-(trifluoromethoxy)benzene; m-(Trifluoromethoxy)benzyl bromide; 3-Trifluoromethoxybenzyl bromide; 3-(Trifluoromethoxy)benzylbromide; (3-Trifluoromethoxyphenyl)methyl Bromide
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethoxy)Benzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its light-sensitive nature and reactivity, it is recommended to store under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.