Description

Fmoc-L-Cys(Phacm)-Oh CAS NO 159680-21-4 is a protected cysteine derivative widely used in solid-phase peptide synthesis (SPPS). This compound is essential for the controlled introduction of cysteine residues, enabling the formation of disulfide bonds critical for the structure and function of therapeutic peptides and proteins. It is a key building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing peptide-based drugs, diagnostics, and research reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the controlled incorporation of cysteine into peptide chains.
• Therapeutic Peptide Production: Synthesis of complex peptides requiring specific disulfide bridge formation for biological activity.
• Antibody-Drug Conjugate (ADC) Development: Used in the synthesis of linker-payload constructs that target cysteine residues on antibodies.
• Research & Development: A critical reagent in academic and industrial labs for studying protein folding, structure-activity relationships, and novel peptide design.
• Bioconjugation Chemistry: Serves as a precursor for creating thiol-reactive probes, labels, and surface modification agents.
• Combinatorial Chemistry Libraries: Used to generate diverse peptide libraries for drug discovery and screening applications.

Basic Information

Product Name	Fmoc-L-Cys(Phacm)-Oh
CAS No.	159680-21-4
Molecular Formula	C27H26N2O5S
Molecular Weight	490.57 g/mol
Synonyms	Fmoc-Cys(Phacm)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-(phenylacetamidomethyl)-L-cysteine; Fmoc-S-(Phenylacetamidomethyl)-L-cysteine; Fmoc-L-Cysteine(S-phenylacetamidomethyl); Nα-Fmoc-S-(phenylacetamidomethyl)-L-cysteine; Fmoc-Cys(Phacm)-OH; (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(phenylacetamidomethyl)sulfanyl]propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-L-Cys(Phacm)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and residual solvent levels is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.