Description

Piperidine, 2-Methyl-1-(Trifluoroacetyl)-, (R)- (9Ci) is a chiral, fluorinated piperidine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its unique stereochemistry and the trifluoroacetyl group, which are essential for modulating the biological activity and physicochemical properties of target molecules. This high-purity intermediate is primarily needed by pharmaceutical R&D and fine chemical manufacturers developing novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Agrochemical Synthesis: Used in the production of advanced, fluorinated pesticides and herbicides where the stereochemistry influences efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Employed in the multistep synthesis of complex, high-value fluorinated organic compounds for research and industrial applications.
• Material Science Research: A potential monomer or modifier in the development of specialty polymers with tailored properties.

Basic Information

Product Name	Piperidine, 2-Methyl-1-(Trifluoroacetyl)-, (R)- (9Ci)
CAS No.	159651-12-4
Molecular Formula	C8H12F3NO
Molecular Weight	195.18 g/mol
Synonyms	(R)-2-Methyl-1-(trifluoroacetyl)piperidine; (R)-1-(Trifluoroacetyl)-2-methylpiperidine; 2-Methyl-1-(trifluoroacetyl)piperidine, (R)-; (R)-2-Methyl-N-(trifluoroacetyl)piperidine; (R)-N-(Trifluoroacetyl)-2-methylpiperidine; (R)-α-Methyl-1-(trifluoroacetyl)piperidine; (R)-1-(2,2,2-Trifluoroacetyl)-2-methylpiperidine
EINECS	Contact for details

Quality Control

Our production of (R)-2-Methyl-1-(Trifluoroacetyl)piperidine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, GC, NMR, and mass spectrometry to confirm identity, enantiomeric excess (ee), and purity. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible materials. Due to its sensitivity, the container should be kept tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.